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KMID : 0371319960500060940
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Journal of the Korean Surgical Society
1996 Volume.50 No. 6 p.940 ~ p.946
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DNA Ploidy and S-phase Activity in Breast Cancer and its Relationship to Prognosis
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권오중
서준석/정중기/홍인규/장미수/윤익진/김민영/노동영/최국진
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Abstract
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To evaluate the prognostic significance of DNA ploidy and S-phase fraction (SPF) in breast cancer, we performed flow cytometry on archival paraffin blocks of primary breast cancers from 67 patients treated at Seoul City Boramae Hospital from Jan.
1988.
to Dec. 1994.
DNA ploidy and PSF were examined in univariate analyses along with tumor size, lymph node metastasis, number of positive nodes and age. Ploidy analysis showed that 85% f tumors were diploid and 15% were aneuploid. There was no difference in
overall
survival(p=0.9945). The median SPF was 11.5% and it was used as a cutoff point. By use of a SPF greater than 11.5% as a prognostc variable, there was no difference in overall survival(p=0.9909). But there was a correlatinship between DNA ploidy
and
SPF,
in other words aneuploidy showed a tendency to have a high SPF.
Even though these results suggest that DNA ploidy and SPF by flow cytometry are not clinically useful independent prognostic factors, it will be necessary to measure them in a large number of patients and then follow these patients so that
multivariate
survival analyses can be performed to evaluate the clinical significance of these factors.
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KEYWORD
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